10/22/2023 0 Comments Pure tuber 2.9.1.101![]() Progress on cocrystallization of poorly soluble NME’s in the last decade. Overview of milling techniques for improving the solubility of poorly water-soluble drugs. Salt formation to improve drug solubility. Molecular properties of WHO essential drugs and provisional biopharmaceutical classification. Kasim NA, Whitehouse M, Ramachandran C, Bermejo M, Lennernäs H, Hussain AS, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Enhancing the solubility and bioavailability of poorly water-soluble drugs using supercritical antisolvent (SAS) process. Bioavailability enhancement of an active substance by supercritical antisolvent precipitation. Majerik V, Charbit G, Badens E, Horváth G, Szokonya L, Bosc N, et al. Comparison of wet milling and dry milling routes for ibuprofen pharmaceutical crystals and their impact on pharmaceutical and biopharmaceutical properties. Kumar D, Worku ZA, Gao Y, Kamaraju VK, Glennon B, Babu RP, et al. Finally, opportunities for future research are also proposed. The advantages and limitations of these processes are also discussed. The success of these processes in enhancing the dissolution rate and bioavailability of many active pharmaceutical ingredients (APIs) has been critically examined. This review critically summarizes the milling, spray drying, high-pressure homogenization, liquid anti-solvent crystallization, spray freeze-drying, supercritical carbon dioxide \((\mathrm)\)–based micronization processes, pulsed laser ablation and combinative techniques. Non-conventional processes such as liquid anti-solvent crystallization, supercritical anti-solvent process, rapid expansion of supercritical solutions, particles from gas saturated solutions, and pulsed laser ablation are emerging as potential alternatives to overcome the disadvantages of conventional processes. However, a few disadvantages such as a broader particle size distribution (PSD) and thermal and chemical degradation of the product are major concerns for the product quality. Conventional processes such as milling, high-pressure homogenization, and spray drying are well established and widely used for particle size reduction. Particle size reduction is one such method that increases the surface area of the pharmaceutical compounds and subsequently leads to a higher dissolution rate and bioavailability. Therefore, solubility enhancement, a key factor for higher bioavailability, is a major challenge in pharmaceutical industries. In pharmaceutical research and development, various new chemical entities (NCE) are found to be poorly water-soluble.
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